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カタログ番号 | 製品名 | 別名 | ターゲット |
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T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T41008 | BODIPY-Cholesterol | BCh2 | |
BODIPY-Cholesterol (TF-Chol) is a cholesterol analog with a fluorescent BODIPY motif and cellular permeability, and is a novel BODIPY cholesterol probe.BODIPY-Cholesterol can be used to study intracellular sterol uptake ... | |||
T36126 | TMP-153 | ||
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste... | |||
T24855 | TASIN-1 Hydrochloride | TASIN-1 HCl,TASIN 1 HCl,TASIN1 HCl | APC |
TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apopt... | |||
T83658 | SQLE-IN-1 | Antifungal | |
SQLE-IN-1 is a squalene epoxidase (SQLE) inhibitor with anti-tumor activity. It can inhibit the proliferation and migration of liver cancer cell line Huh7, inhibit the production of cellular cholesterol, and increase the... | |||
T19159 | Mal-β-CD | 6-O-alpha-D-Maltosyl-beta-cyclodextrin | Others |
T37846 | Taurohyocholic Acid (sodium salt) | ||
Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline ... | |||
T37853 | Cholesteryl Lignocerate | ||
Cholesteryl lignocerate is a cholesterol ester that has been found in human meibum. Cholesteryl lignocerate can be hydrolyzed by cellular extracts from cultured human skin fibroblasts isolated from healthy individuals bu... | |||
T25356 | E17110 | E-17110,E 17110 | |
E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cel... | |||
T13483 | RP 54275 | 2-Octadecyl-1H-indole-5-carboxylic acid | Others |
RP 54275 is a naturally occurring fatty acid derivative, a new cholesterol-lowering compound. It activates the peroxisome proliferator-activated receptor gamma (PPARγ) pathway, which is involved in the regulation of lipi... | |||
T37953 | Sphingomyelins (buttermilk) | ||
Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surr... | |||
T76156 | Sphingomyelin phosphodiesterase | ||
Sphingomyelin phosphodiesterase, a hydrolase, plays a crucial role in sphingomyelin metabolism by catalyzing the conversion of sphingomyelin into phosphocholine and ceramide. Furthermore, it is instrumental in cellular d... | |||
T83683 | St-Ht31 ammonium | sHt31 | |
st-Ht31, a cell-permeable stearated peptide derived from the amphipathic helix domain of A-kinase anchoring proteins (AKAPs), effectively binds protein kinase A (PKA), impacting PKA's cellular interactions without alteri... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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TN4016 | Ethyl 2,4,6-trihydroxybenzoate | Liver X Receptor | |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular ch... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-00007 | HMGCR Protein, Human, Recombinant (His) | Human | E. coli |
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol ... | |||
TMPH-02476 | HMGCR Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol ... | |||
TMPK-01291 | ANXA1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | E. coli |
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ... | |||
TMPK-00799 | ANXA1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ... | |||
TMPK-00768 | ANXA1 Protein, Human, Recombinant (His) | Human | E. coli |
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activ... | |||
TMPH-01623 | GBA Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the tu... | |||
TMPH-01624 | GBA Protein, Human, Recombinant | Human | E. coli |
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the tu... | |||
TMPY-04813 | ACAT2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e... | |||
TMPY-00131 | Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 Cells |
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pi... | |||
TMPJ-00833 | MPO Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride,... |